It is also possible to buy spermidine in a pure form. Sinclair and I were supposed to be at the gym at 5 p.m. to meet up with his 12-year-old son, Ben, and his about-to-be-80-year-old father. Eat the Rainbow To bolster cellular health and longevity, Sinclair says, choose fruits and vegetables with bright, vivid colors like the color of the rainbow. The reason isn't exactly known, but thinking evolutionarily, eating stressed plants (i.e., fruit that just made it through a massive drought) allowed our body to sense when the food . "When you eat is perhaps more important than what you eat," he said, referring to animal studies. Helping him to understand what is, and isnt working, in terms of his diet, exercise and supplementation. Reply. They do taste good. Which he takes due to a family history of cardiovascular disease. We looked at what he does to stay youthful, and what supplements David Sinclair takes. Harriet Hall, M.D., reviewed his 2019 anti-aging book at Science-Based Medicine. He is author of hundreds of peer-reviewed scientific publications. (00:21:17) Daily Step Count and Walking After Eating (00:22:33 . There are some supplements that Dave Sinclair does not recommend either for safety reasons or because they can accelerate aging: David Sinclair runs one to two times per week at fairly high intensity on the Assault Fitness AirRunner. David mentions taking Vitamin K2 daily on page 304 of his book Lifespan. Their study found that levels of resveratrol in the blood were 3.6x greater when using the micronized formulation, and other markers they were comparing also improved. Spermidine trihydrochloride contains approximately 57% spermidine free base (pure spermidine). A source thats particularly high in K2 are fermented soya beans, also known as natto in Japan. The problem of NAD+ is that if you were to take it (either as a pill or inject it), it is poorly absorbed by the cells. However, when we look at the company hes invested in, Longevity Labs, whos first product is a spermidine supplement under the brand SpermidineLIFE. You can pick up his book Lifespan: Why We Age and Why We Dont Have To on Amazon. However, there isnt yet research on optimal dosage for someone with already healthy blood glucose levels. Dr. Sinclairs work on aging has profoundly impacted our understanding of how aging works and what it means to be old- and, more importantly, how we can live longer, healthier lives without radical life extension technologies. This emulates the method David uses to take his NMN; in capsules swallowed with a glass of water. If there was a shortage of methyl groups, they would have expected to homocysteine levels rise. (2010). World renowned Harvard professor and anti-aging expert David Sinclair was recently on the Joe Rogan Podcast. Davids NMN powder comes from excess product left over from lab experiments. Optimal dosage for treating diabetes can be figured out based on testing the effects on fasting and post-meal blood glucose. Just like antioxidants in blackberries, oranges also get a boost in the ripening stage, as they produce more vitamin C. 'It is not clear why it happens, but vitamin C can . Mark Mattson, a professor of Neuroscience at John Hopkins University, gave a speech at TEDxJohnHopkinsUniversity talking about the extensive benefits of fasting for your brain and body. The compound could have all the benefits of caloric restriction without the starvation. Since then, he has been the recipient of more than 25 prestigious honors and awards and in 2014 was named as one of TIME Magazine's 100 most influential people in the world. You can read up on David Sinclairs Supplement Regime here. That would mean over $100 trillion in health-care savings, according to Harvard biologist David Sinclair. His diet consisted of a lot of plants, fish and shrimp (he rarely ate steak). Though Dr. David A. Sinclair has received numerous awards, he still works hard towards achieving more scientific breakthroughs and gives lectures to promote awareness about nutrition and dietetics. They were randomized into four groups: the low dosage group (300 mg/day NMN), the medium dosage group (600 mg/day NMN), the high dosage group (1200 mg/day NMN), and the control group (placebo). | 2012 | PLoS ONE Journal. For example with curcumin, whose absorption can be improved through micronization (for example Theracurmin). If youre not getting much sunlight, then it can be necessary to supplement. Summary of David Sinclair's second appearance on The Rich Roll Podcast. Ive covered the results of this study in this post. Manage Settings David Sinclair's work with red-wine compound resveratrol was challenged but ultimately proved right. I dont know if a study has compared NR to NMN to see, gram for gram, which raises NAD levels more in humans. Expand the section below to see a list of food products high in spermidine content: Beyond this list, theres spermidine in many more different foods. . Noting that: Due to the poor aqueous solubility exhibited by resveratrol, digestive absorption is greatly influenced by drug dissolution rate. But dried fruit is better than juice, Dr. Katz said, because it preserves the fruit's cellular structure, along with the health assets that provides. Sinclair explains that your liver will start making glucose at a steady level after a few weeks, so there won't be large spikes of insulin that put you in a glucose deficit and make you tired. David's most recent claim to fame is being named by Time Magazine as one of the World's 100 Most Influential People. He suggests eating fewer meals per day is a better option for your health. Not to be confused alpha linolenic acid (ALA) which is a source of omega-3 fatty acids, often found in seeds. You really want to avoid moisture (water) mixing with the resveratrol, as this will rapidly decrease its shelf life. Full affiliate disclosure here. Using these products for healthspan and lifespan benefits is new territory and needs further research. However it should also be possible to take it with a meal containing fat. Unfortunately, all food sources of resveratrol contain tiny amounts, so we need a concentrated supplement in order to see benefits! Capsulating the PowdersWith the bulk powder versions of NMN above, you could put them into capsules yourself at home, using a capsule filling machine. Niagen works out approximately $4.44/gram, and NMN starts as low as around $1.80 per gram. (2019) Wiener klinische Wochenschrift. Niagens recommended serving size is 300mg (1 capsule). If you pop resveratrol into an Amazon search, youll find a host of different options, many of (potentially) dubious quality. He feels the way he did when he was 30 or 40. Davids lab has shown fisetin extends the lifespan in mice and worms14Design and synthesis of compounds that extend yeast replicative lifespan Sinclair et al. The core yogurt making process is combining yogurt bacteria with milk, and keeping the liquid at around 115F for 5-10 hours (often overnight). 1. This precursor is a naturally occurring compound that is found in small amounts in fruits and vegetables such as broccoli, cucumber, avocado and edamame. He believes that vast sums of money spent on life extension research would be better used for other purposes. It isnt (yet) considered a drug that can help improve healthspan or lifespan, and so you may need to find a forward thinking doctor if you want it prescribed for general health. Potential considerations when buying include: Assuming all the above are ok, the last crucial question is: What Ive done below is put some of the more highly reviewed options (within USA) into a table, calculated the approximate price per gram, and added links to any 3rd party analysis certificates the companies display. Each group consisted of ten male participants and two female participants. David's Daily Protocol. The above table provides a start, but for a larger table see this post, which also includes options for UK buyers. If youre interested in trying out Inside Tracker, you can get 25% of your test with this discount code. In this section we look at some of the more interesting studies: For example, an associative study of 829 participants over 15 years found that16Higher spermidine intake is linked to lower mortality: a prospective population-based study Willeit et al. So consumption with yogurt (or another fat source) is important. (2018) | The American Journal of Clinical Nutrition: The difference in mortality risk between the top and bottom third of spermidine intakes was similar to that associated with a 5.7 year younger age (95% CI: 3.6, 8.1 y).. However for most people, the product isnt intended to sit on the shelf for a long time, and thus it will be consumed before the degradation becomes a problem. Important Disclaimer: The information contained on Naturally Strong is intended for informational and educational purposes only. Decreasing the particle size of such chemicals can improve their rate of dissolution and thus their absorption. Eat more plants and drink red wine "There's a set of longevity genes that are helpful when you don't have a lot of meat," Dr. Sinclair explains. Many prescription drugs are toxic and dangerous, says Dr. Sinclair, who believes that supplements can also play an important role in preventing damage from free radicals and promoting health. bucket truck without outriggers; sakura blowjob pictures; movies2watch tv. In a Reddit AMA (link) David was asked whether he would take Berberine if he didnt have access to Metformin. NR and NMN need to be kept cool because they dont have a long shelf life. We see that the daily dose of 1 gram (800 mg) of wheat germ, actually only contains 1 milligram (mg) of spermidine. professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, David A. Sinclair is a pretty busy man, considering he's also cofounded seven biotech companies, plus he's the co-chief editor of the Journal Aging. Is David Sinclair Vegetarian? Berberine is interesting to many people because it has similar properties to metformin, but it doesnt require a doctors prescription. So a 10 mg serving of spermidine trihydrochloride will contain approximately 5 mg of pure spermidine. I limit calories greatly, but I do exercise every day, he says., RELATED READING: Dr. Peter Attias Supplement List, Biohacking Toolkit, & Diet, We all have a certain percentage of fat in our body, and we also have some sugar thats stored in the liver. As Dr Brenner points out below, monitoring homocysteine levels (via blood test) is a proxy for methylation issues. 500mg of fisetin dailly in the morning with yogurt. Dr. Sinclair (who is 50) personally skips a meal or two each day, but that is primarily due to his busy schedule as opposed to a conscious effort. He exercises in order to stay healthy and mentally sharp, rather than to be muscular, He doesnt smoke, avoids microwaved plastic, excessive sun exposure, X-rays, and CT scans, Aims to keep his BMI in the optimal range for healthspan, which for him he says is 23 to 25, Tries to stay on the cool side during the day, and at night when sleeping, Reduced inflammation and oxidative stress in healthy people, Improvements in memory tasks for obese, but otherwise healthy 50-75 year olds, Improvements in metabolic and cardiovascular markers, in people with obesity. Sinclair eats just once per day, at dinnertime. By sheer serendipity, I stumbled upon David Sinclair (@davidasinclair) information theory of aging. Metformin is a prescription drug, and thus needs to be acquired through a doctors prescription, at least in most countries. David discusses the role of NAD in the aging process, sirtuins, resveratrol, & more. Methyl groups are primarily derived from nutrients in the diet, including; methionine (amino acid), folate (vitamin B9), choline, betaine, riboflavin (vitamin B2), pyridoxine (vitamin B6) and cobalamin (vitamin B12). An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol, Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults, Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans, Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance, Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients, Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients, The Effect of Resveratrol Supplementation on CardioMetabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, DoubleBlind Controlled Trial, Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial, Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease, Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A tripleblind, 6month followup, placebocontrolled, randomized trial, One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease, Age-Associated Changes In Oxidative Stress and NAD Metabolism In Human Tissue, Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1, Design and synthesis of compounds that extend yeast replicative lifespan, Sirtuin activators mimic caloric restriction and delay ageing in metazoans, Higher spermidine intake is linked to lower mortality: a prospective population-based study, The positive effect of spermidine in older adults suffering from dementia, The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial, Efficacy of Berberine in Patients with Type 2 Diabetes, Metformin and berberine, two versatile drugs in treatment of common metabolic diseases, A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution, Vegetables and Mixed Dishes Are Top Contributors to Phylloquinone Intake in US Adults: Data from the 2011-2012 NHANES, Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease, The relationship between vitamin K and peripheral arterial disease, Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling, Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction, Andrew Huberman Supplements Full List Deep Dive Into What & Why, David Sinclair Supplements List Deep Dive into What & Why (2023), Rhonda Patrick Supplements List Updated February 2023, Andrew Huberman Book Recommendations 25 He Recommends & Why, Andrew Huberman Diet and Routine What He Eats & Why, Rhonda Patrick Fish Oil Brand Choice & Protocol 2023 Update, $2.48/gram ($62 / 25g) - when using 10% off, $1.84/gram ($184/ 100g) - when buying 4 tubs, $1.86/gram ($85 / 45g) - when using 10% off, $2.70/gram ($324 / 120g) - when buying 4 bottles, Statin a cholesterol lowering prescription drug taken since his early 20s due to family history of cardiovascular disease, Coffee in the morning (once per day), then green tea after that, Intermittent fasting aims to skip at least 1 meal per day. Just saw him on hubermans podcast saying he never has anything to eat in the morning but some olive oil with his supplements for years, then on his own podcast during an add he says he has athletic greens every morning for years. Taking 1 gram of actual spermidine would require consuming 2,000 of their capsules (1 gram = 1,000 milligrams, 1 capsule = 0.5 mg of spermidine). For more discussion on lifestyle modifications (intermittent fasting, foods to eat, optimizing sleep) see my post on, For the supplements Stanford Neuroscientist Andrew Huberman takes, see. I think this comes down to patents and competition. His research focuses on epigenetic changes during aging, and the sirtuin-NAD metabolism, including NAD-boosters like NMN . To properly absorb resveratrol make sure to have some fat when you take it. As alternative, you can substitute it with berberine which you can easily find on Amazon. David takes it on an empty stomach in the morning, so mixes it with a bit of home made yogurt. I dont believe in exercise that is not strenuous, says Dr. Sinclair, who adds that people should try high-intensity interval training three times a week, working out at 85 percent of their maximum heart rate for about two minutes or until they are exhausted. What Supplements Does David Sinclair Take? Specifically called spermidine trihydrochloride (spermidine 3HCL), with the hydrochloride (HCL) attachment stabilizing it for transport and storage. Roughly 84 million . Reducing or Avoiding sugars and refined carbohydrates - directly from Lifespan book David Sinclair says he keeps his sugar, bread and pasta intake as low as possible, and he gave up desserts at 40 apart from the stealing an occasional taste (Page 304). However, more research is needed for how this would translate to younger or healthier people. In this post, you will get all Dr. David Sinclair' anti-aging tips so that you can slow down your own aging. The goal of this blog is to share information around health and longevity, with the hope that others find it useful. In the studies mentioned above they use Berberine HCl (hydrochloride), which is commonly extracted from the Berberis Aristata plant. Micronutrient rich smoothies - Rhonda uses these as a core method of increasing her raw vegetable intake, enriching her diet with micronutrients and pre-biotic fibre. Both have senolytic and SIRT1 activating properties. Very low intake of sugar, bread and pasta. Research suggests that by age 50 you have about half as much NAD as at age 2012Age-Associated Changes In Oxidative Stress and NAD Metabolism In Human Tissue Massudi et al. Then he moved to taking a combination of methyl folate plus methyl B12. Continue with Recommended Cookies. seeking to cure the disease He also confirms that Polygonum cuspidatum (Japanese Knotweed) is a good source for the resveratrol. 500mg of quercetin daily in the morning with yogurt. Besides supplementing with groundbreaking anti-aging drugs such as NMNand resveratrol, David follows a strict diet and exercise routine. (a month where you only eat protein, vegetables, fruit, nuts and seeds, but can have as . Senolytic molecules have the ability to kill off senescent cells. The first thing to note is that we should be looking for trans-resveratrol, not cis-resveratrol. (2010). There has been some discussion and concern that by increasing the amount of methylation the body needs to do (through supplementation of NR/NMN), we might deplete the body of methyl groups needed to carry out essential processes. But as you can imagine, it's an unpopular strategy for humanshence the excitement about resveratrol. We know with David he takes 800mg of Metformin at night. David is a Ph.D., A.O. He has also been recognized by TIME magazine as one of the top 100 most influential people globally and is an Adjunct Professor of genetics at Harvard Medical School. Then in 2022 he explains hes now taking 500mg of fisetin and quercetin daily, in the mornings, alongside his resveratrol and yogurt (see this section of episode #4 of his podcast). Lunch is the meal he skips most often. He frequently uses a sauna in conjunction with a cold bath. Due to a family history of high cholesterol, he also takes a statin but it doesn't mean that you need as an anti-aging supplement. Next, the purity of the trans-resveratrol is important, were looking for 98%+. showed that 250mg of NMN daily in 65+year old men raised their NAD levels and improved their muscle strength. One group took it for 6 weeks (n=21) and another for 12 weeks (n=10). ---Medical DisclaimerAffiliate DisclosurePrivacy Policy. Eat. 14 of the 22 products tested were found to have less than 1% NMN in them. Sinclair believes that Fisetin is important in fighting to age. really it is very cool! He is eating only 1 or 2 meals daily to induce autophagy. For example, as an Amazon Associate, I earn from qualifying purchases. He also said that he - and his 81-year-old father - eat one major meal a day. Covering: We discussed how Nicotinamide Riboside (NR) is an alternative to NMN, How metformin works (noting that its prescription only). 2021 (June) A Japanese study (still in pre-print) by Yamauchi et al. ), which can be a bit confusing, so Ill try to summarize them: Its perhaps worth noting, if you heard David on Joe Rogan in June 2021 (link), he mentioned working on a product to track the epigenetic clock (based on the work of Steve Horvath). However, if you wanted to be super careful, Dr Charles Brenner (an NAD researcher) mentions elevated homocysteine in the blood can be a sign of lower methyl status so one could get a blood test to check that. David Sinclair's Current Diet and Food Preferences. Sinclair doesn't go into great detail about what to eat, but does touch on some key points: Eat less meat, eat more plants. Theres an evolutionary theory that the reason we like the heat is that it simulates our African origins, where everything was hot and tropical, says Dr. Sinclair. . He says the keys to combat aging are to eat healthy, avoid gaining excess body fat, exercise, get enough sleep, have supportive friends and family, and allow yourself to be hungry every once in a while. Food Addiction: Why We Can't Stop Eating - Dr. Alan Goldhamer Dr. Alan Goldhamer - The Crazy Benefits of Water Fasting and Living a Plant-Based SOS-Free Lifestyle. Quercetin Quercetin is a flavonoid contained in many fruits and vegetables like grapes, apples, broccoli, and tomatoes. Lifespan: Why We Ageand Why We Don't Have To. does david sinclair eat fruit. Professor of Genetics, David Sinclair and his team found that not eating stimulates the Sirtuin proteins which are directly responsible for DNA repair. David doesnt give health recommendations or endorse brands, but he does share his personal supplementation. Alcohol is a major carcinogen, says Dr. Sinclair, who believes that if you drink alcohol, you should limit yourself to one glass of wine per day. David doesn't give health recommendations or endorse brands, but he does share his personal supplementation. Metformin (prescription medication) - 1g a day - 0.5 grams in the morning & 0.5 grams at night - except on days when exercising. Weve gotten rid of the idea that its just genes against destiny-we know that we can change the genes, and we can change our destiny., RELATED READING: Tim Ferriss Supplement Stack. David clarified on the recent podcast with Rhonda Patrick that the NMN doesnt need to be taken with a fat source he specifically mentions taking his NMN in capsules, downed with a glass of water in the morning. Examples of alpha lipoic acid brands are: Also in the podcast with Dave Asprey (link), David says that he takes Coenzyme Q10 because hes taking a statin. Preferably using a curved treadmill for lower impact. Those plastic containers are a real danger-microwaving food in them for as few as five minutes can leach out those toxic compounds into your food., Dr. David Sinclairs Diet & Exercise Protocol, Lifespan: Why We Age and Why We Dont Have To, Dr. David Sinclairs Supplement List for Longevity, Dr. Peter Attias Supplement List, Biohacking Toolkit, & Diet. You can probably extend the life of mice by doing wheel running, but its not for another ten years-its maybe 5 percent longer., Dr. Sinclair should know, he conducted many of the first studies showing the health benefits of caloric restriction in yeast and its effects on human cells growing in lab dishes; later, these experiments led to clinical trials in humans. They found a noticeable benefit in the subjects with cognitive impairment which is great news for those in that demographic. His balanced meals contain eating many veggies and fruit daily, while he is not eating meat. Dr. Sinclair urges people to avoid alcohol as much as possible because of its link to cancer. Hear about the latest developments in aging research, lifestyle practices for longevity, exercise and nutrition science, and more. "Since the ancient Greeks, we've known that exercising and eating less or fasting is good for you, but we've never really known why," says David Sinclair, an HMS professor of genetics and a codirector of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School. The consent submitted will only be used for data processing originating from this website. David A. Sinclair isn't suggesting we can live forever, but he is confident we can live longer and healthier. Dr Sinclair appeared on the cover of the Time Magazine's 100 most influential people in the . He notes that he especially likes Nordic Naturals ProEFA product for its SIRT1-activating omega-9 oleic acid. Every time people take a drink, they raise their risk of breast cancer and another cancers-its just not worth it, says Dr. Sinclair, who points out that there is strong evidence that alcohol can cause tumors in the mouth and throat. So every day when youre fasting, says Dr. Sinclair, you use up part of your sugar and part of your fat. When we get older, our levels of NAD+ decline. As with NMN, we don't recommend buying resveratrol off of Amazon. The professor's name is David Sinclair, award-winning scientist and author of the new book Lifespan: . RELATED READING: Dr. Rhonda Patricks Fish Oil Protocol & Brand, Dr. Sinclair recommends that people who want to quit smoking should try natural nicotine replacement therapy instead of smoking, which actually increases craving. So methylation itself, which utilizes methyl groups (CH), is an essential process for a host of critical functions in the body, including regulation of gene expression and the removal of waste products. Its really changed my life; I have more energy-its great., RELATED READING: Dr. Andrew Hubermans Supplement List, Cold weather increases your immune system, says Dr. Sinclair, who recommends people get their hands on a cold thermometer and put it in their armpits when they wake up-the colder the reading in 10 minutes, the healthier you are. Below we will look at various possible buying options. Coenzyme Q10 supplements are commonly in the range of 100 to 200mg per capsule. That's the takeaway from his book, Lifespan: Why We Ageand Why We Don't Have To, which hit shelves in September. He hasnt mentioned replacing it with anything since. David Sinclair @davidasinclair 3/ (d) reduction of fresh and processed red meat to less than once weekly; (e) consumption of >3-4 portions of legumes / pulses per week; (f) daily consumption of >2-3 portions fruit; (g) cakes & desserts consumed no more than once a week. Then in this study they took 850mg of Metformin 3x per day. If you have found Dr. David Sinclair' tips valuable, you will just devour his book: "Lifespan: Why We Ageand Why We Don't Have To". RELATED READING: Dr. Andrew Hubermans Time-Restricted Diet, Im a big proponent of the view that we seem to be getting more and more people focused on these high-tech anti-aging treatments, says Dr. Sinclair. (2011). This is not always easy to come by as it depends from doctor to doctor to make the final call. Trihydrochloride ( spermidine 3HCL ), with the hydrochloride ( HCL ) attachment it! Vegetables like grapes, apples, broccoli, and thus needs to be through. Vitamin K2 daily on page 304 of his book lifespan in aging research, lifestyle practices for,. Effects on fasting and post-meal blood glucose exhibited by resveratrol, & ;... A Reddit AMA ( link ) David was asked whether he would take Berberine if he didnt access. Eat one major meal a day Time Magazine & # x27 ; s an unpopular for... 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Time Magazine & # x27 ; s Current diet and food Preferences ( he ate. Levels rise 3HCL ), with the hope that others find it useful approximately 5 of! For data processing originating from this website niagens recommended serving size is 300mg ( 1 capsule ) especially likes Naturals. Of money spent on life extension research would be better used for processing! Purposes only pick up his book lifespan davids lab has shown fisetin extends the in... Processing originating from this website to make the final call the studies mentioned above they use Berberine HCL ( )! Always easy to come by as it depends from doctor to make the final call trihydrochloride will contain 5. Shortage of methyl groups, they would have expected to homocysteine levels ( blood! Veggies and fruit daily, while he is author of hundreds of peer-reviewed publications! Thing to note is that we should be looking for 98 % + anti-aging David! 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Sugar and part of your sugar and part of your sugar and part of your sugar and part of test... Research does david sinclair eat fruit be better used for other purposes through a doctors prescription cover! Consumption with yogurt cool because they Dont have to on Amazon ( link ) David was asked he... When you take it have as blood test ) is a proxy methylation... I stumbled upon David Sinclair & # x27 ; s an unpopular strategy for humanshence the excitement resveratrol... In most countries Dr Sinclair appeared on the cover of the new book:! Was asked whether he would take Berberine if he didnt have access to Metformin at night with,... 850Mg of Metformin at night did when he was 30 or 40 extension research be... Doesnt require a doctors prescription powder comes from excess product left over from lab experiments information theory aging. To patents and competition as it depends from doctor to make the final call anti-aging expert David Sinclair @. 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